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DeCS
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Descriptor English:
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von Willebrand Factor
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Descriptor Spanish:
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Factor de von Willebrand
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Descriptor Portuguese:
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Fator de von Willebrand
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Synonyms English:
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Factor VIII-Related Antigen
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Tree Number:
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D12.776.124.125.920
D23.119.985
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Definition English:
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A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in von Willebrand's disease is due to the deficiency of this factor. |
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Indexing Annotation English:
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DF: VWF
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Entry Combination - descr/qualif English:
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von Willebrand Factor/deficiency use von Willebrand Disease
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See Related English:
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Coagulants
Weibel-Palade Bodies
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History Note English:
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86(76); was see under BLOOD COAGULATION FACTORS 1976-85; FACTOR VIII RELATED ANTIGEN, previously in the Supplementary Chemical File, was mapped to both FACTOR VIII & ANTIGENS 1977-89
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Allowable Qualifiers English:
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Record Number:
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22305
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Unique Identifier:
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D014841
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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